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How Does Nivolumab (Opdivo) Work?

Nivolumab blocks the activity of a molecule called PD-1, a protein that prevents T cells from recognizing and attacking inflamed tissues and cancer cells. PD-1 can trick your immune system into overlooking melanoma cells as normal cells.

Nivolumab triggers your immune system’s response to melanoma by blocking the PD-1 protein on T cells. The drug activates T cells so that they can attack melanoma cells anywhere in your body.

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